Endocrine Abstracts

IntroductionThe thresholds of late night salivary cortisol (LNSC) vary widely among studies due to differences in assay methodologies and in control groups. We aimed to verify the analytical performance of the LNSC by electrochimiluminescence assay (ECLIA) and to establish cut-off values of LNSC for the screening of Cushing’s syndrome (CS).MethodsPatients with suspected CS underwent screening tests inclu...

IntroductionEctopic thyroid gland (ETG) is a rare developmental disorder, and when occurs in the midline of the neck, it mimics the clinical presentation of thyroglossal duct cyst (TGDC). inadvertent surgical removal of ETG simulating TGDC has been reported in the literature in spite of the modern diagnostic methods for this pathology.1, 2. We report a case of a 27-year-old female with Hashimoto’s thyroiditis of ectopic thyroid in whom a ...

Introduction: Primary hyperaldosteronism is the first cause of secondary hypertension during pregnancy. The diagnosis is too difficult due to the changes in the renin angiotensin system.Observation: We report the case of a 37 years old women with a history of pre-eclampsia during her pregnancy who consulted the emergency 20 days after delivery for severe hypertension (23/11) and severe hypokalemia (2.2 mmol/l ) resistant to intravenous treatment. The ald...

Introduction: Thyroid storm is an acute exacerbation of hyperthyroidism, responsible for significant mortality despite treatment.Case report: We report the observation of a 43-year-old diabetic patient with basedow’s disease with poor therapeutic adherence; admitted for convulsions and loss of consciousness. The diagnosis of acute thyroid storm on drop out of treatment was mentioned, in front of the detection of peripheral hyperthyroidism with low ...

We present the case of a 51 years old woman, nonsmoker, without relevant past medical history, who presented with acute psychotic state starting the third day of treatment with prednisone 30 mg indicated for allergy. She had also arterial hypertension and a significant and progressive loss of proximal muscle strength in her legs. The initial evaluation showed hyperglycemia, metabolic alkalosis and severe hypokalemia. Basal plasma cortisol was high (>90 μg/dl) and did ...

We present a 38-year-old patient who had adrenal insufficiency following laparoscopic removal of 3.2 cm cortisol-secreting right adrenal tumour. His biopsy showed adrenocortical adenoma in keeping with Cushing’s syndrome. He had a history of hypertension with suboptimal control despite being on 3 anti-hypertensives. His early morning cortisol (by GP to investigate secondary causes) were elevated and this prompted Endocrine referral. Clinical history and examination were ...

Purpose: The postoperative levels of cortisol and ACTH are the most commonly used markers for the prediction of Cushing’s disease (CD) remission after transsphenoidal surgery (TSS). However, there is still no consensus on the collection time and threshold values of basal cortisol and ACTH levels after surgery to predict remission of CD.Aim: To study the significance of early postoperative serum cortisol and plasma ACTH testing in the prognosis of C...

Introduction: Cushing’s disease (CD) is associated with significant morbidity and mortality due to cerebro-cardiovascular, thrombotic or infectious complications. However, there is significant variation in the clinical presentation and consequences of hypercortisolism, resulting in a wide clinical spectrum, ranging from mild to severe or even life-threatening disease requiring immediate treatment.Aim: The description of patients with severe CD in c...

Dyslipidemiαs should be managed from childhood for prevention of early atheromatic vascular lesions and premature cardiovascular disease in adult life.Aim: We examined the frequency of different types of dyslipidemiα in children and the results on blood lipids of lifestyle intervention (diet and exercise).Patients and methods: We studied retrospectively 136 children, 74 boys and 62 girls, mean chronological age 8.5±3...

Introduction: Hypophysitis is a rare association of inflammatory bowel disease (IBD) with only few cases reported in the literature. It can present with isolated hormone deficiencies or panhypopituitarism. Patients may also present with symptoms secondary to inflammatory pituitary mass. Management consists of hormone replacement therapy, but high dose steroids, steroid sparing agents like Rituximab or even surgery may be required for mass effect.Case rep...